Involvement of the chemokine RANTES (CCL5) in resistance to experimental infection with Leishmania major.

Authors :: Santiago HC
Oliveira CF
Santiago L
Ferraz FO
de Souza D G
de-Freitas LA
Afonso LC
Teixeira MM
Gazzinelli RT
Vieira LQ
Source :: Infection and immunity [Infect Immun] 2004 Aug; Vol. 72 (8), pp. 4918-23.
Publication Year :: 2004
Abstract: The expression and putative role of chemokines during infection with Leishmania major in mice were investigated. CCL5 expression correlates with resistance, and blockade of CCL5 rendered mice more susceptible to infection. CCL5 is part of the cascade of events leading to efficient parasite control in L. major infection.

Subjects :: Animals
Leishmaniasis, Cutaneous parasitology
Leishmaniasis, Cutaneous physiopathology
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Chemokine CCL5 metabolism
Leishmania major
Leishmaniasis, Cutaneous immunology

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