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[Immunosuppressive activity of exopolysaccharide from Paecilomyces gunnii].
- Source :
-
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials [Zhong Yao Cai] 2004 Mar; Vol. 27 (3), pp. 192-5. - Publication Year :
- 2004
-
Abstract
- Objective: To investigate bioactivities of Paecilomyces gunnii exopolysaccharide (PGEP).<br />Methods: The effects of PGEP on mice spleen lymphocytes proliferation, mice peritoneal macrophage (PMphi) phagocytosis and cytotoxin T lymphocytes (CTL) activity were studied by MTT method, neutral red colorimetry, respectively.<br />Results: In vitro, mice spleen lymphocytes proliferation, mice peritoneal macrophage (PMphi) phagocytosis of neutral red and CTL activity were significant suppressed by PGEP, especially in 10 microg/ml.<br />Conclusion: PGEP had the immunosuppressive activities.
- Subjects :
- Animals
Cell Division drug effects
Immunosuppressive Agents isolation & purification
Mice
Mice, Inbred BALB C
Polysaccharides isolation & purification
T-Lymphocytes cytology
T-Lymphocytes, Cytotoxic drug effects
Immunosuppressive Agents pharmacology
Macrophages, Peritoneal physiology
Paecilomyces chemistry
Phagocytosis drug effects
Polysaccharides pharmacology
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1001-4454
- Volume :
- 27
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
- Publication Type :
- Academic Journal
- Accession number :
- 15272783