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Afferent and efferent connections of the parvicellular subdivision of iNTS: defining a circuit involved in taste aversion learning.
- Source :
-
Behavioural brain research [Behav Brain Res] 2004 Sep 23; Vol. 154 (1), pp. 85-97. - Publication Year :
- 2004
-
Abstract
- Conditioned taste aversion (CTA) expression is associated with strong increases in Fos-like immunoreactivity (FLI) in a region of the brainstem identified as the parvicellular subdivision of the intermediate nucleus of the solitary tract (iNTSpc). To identify the projections to and from cells in iNTSpc which display strong FLI in response to expression of a CTA, anterograde and retrograde tract tracing was used. When appropriate, tract tracing was combined with double labeling for FLI in animals which received CTA training as well as tracer injections and were re-exposed to the CS taste. With respect to afferent projections, iNTSpc receives a strong, direct, ipsilateral projection from amygdala and the distribution of the fiber terminals yields a striking match to that of cells expressing FLI after CTA expression. As for efferent projections, these cells in iNTSpc are characterized by a mixed, rather than homogeneous, projection pattern. Targets of these cells include pons and forebrain as well as local medullary sites, all of which are known to be involved in gastrointestinal function. Thus, activation of these cells may provide a circuit through which gastrointestinal/visceral responses are coordinated as a component of the conditioned aversion.
- Subjects :
- Afferent Pathways cytology
Amygdala cytology
Amygdala physiology
Animals
Conditioning, Operant physiology
Efferent Pathways cytology
Neurons metabolism
Paraventricular Hypothalamic Nucleus cytology
Paraventricular Hypothalamic Nucleus physiology
Proto-Oncogene Proteins c-fos metabolism
Rats
Rats, Long-Evans
Solitary Nucleus cytology
Afferent Pathways physiology
Avoidance Learning physiology
Brain Mapping
Efferent Pathways physiology
Solitary Nucleus physiology
Taste physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0166-4328
- Volume :
- 154
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Behavioural brain research
- Publication Type :
- Academic Journal
- Accession number :
- 15302114
- Full Text :
- https://doi.org/10.1016/j.bbr.2004.01.027