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[GERD and tight junction proteins of the esophageal mucosa].
- Source :
-
Nihon rinsho. Japanese journal of clinical medicine [Nihon Rinsho] 2004 Aug; Vol. 62 (8), pp. 1441-6. - Publication Year :
- 2004
-
Abstract
- Recent advancement in the research of GERD has revealed that endoscopy negative GERD may not be a milder form of erosive GERD and may have different pathogenesis. We have previously proven that hypersensitivity to the acid of the esophageal mucosa plays an important role in its pathogenesis. Regarding the mechanisms for the esophageal hypersensitivity, we hypothesized that the tight junction proteins of the esophageal mucosa are fully or partially impaired in GERD patients. Accordingly, we immunohistologically studied the expression of various tight junction proteins using the rat reflux esophagitis model. The results demonstrated that the several kinds of tight junction proteins are expressed differently in the various parts of esophagus and their expression altered according to the development of reflux esophagitis.
- Subjects :
- Animals
Disease Models, Animal
Esophagoscopy
Esophagus cytology
Esophagus metabolism
Gastroesophageal Reflux metabolism
Gastroesophageal Reflux pathology
Humans
Immunohistochemistry
Mechanotransduction, Cellular physiology
Membrane Proteins metabolism
Mucous Membrane cytology
Mucous Membrane metabolism
Mucous Membrane physiopathology
Rats
Esophagus physiopathology
Gastroesophageal Reflux etiology
Membrane Proteins physiology
Tight Junctions metabolism
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0047-1852
- Volume :
- 62
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Nihon rinsho. Japanese journal of clinical medicine
- Publication Type :
- Academic Journal
- Accession number :
- 15344532