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Improvement in the prognosis of Japanese breast cancer patients from 1946 to 2001--an institutional review.
- Source :
-
Japanese journal of clinical oncology [Jpn J Clin Oncol] 2004 Aug; Vol. 34 (8), pp. 457-62. - Publication Year :
- 2004
-
Abstract
- Background: Breast cancer has emerged as one of the most frequent malignancies among Japanese women; however, the long-term survival of Japanese breast cancer patients is uncertain.<br />Methods: We analyzed the chronological changes in the clinical and pathological characteristics, treatment procedures and the long-term prognosis of 15 416 Japanese women with 16 217 primary breast cancers treated in the Cancer Institute Hospital in Tokyo between 1946 and 2001.<br />Results: Our analysis revealed a chronological increase in the mean patient age, postmenopausal patients and non-invasive carcinomas. Operative procedures became less extensive, with approximately 45% of breast cancer patients in 2000-2001 receiving breast-conserving treatment. Radiotherapy to the regional lymph nodes decreased, while postoperative chemotherapy and hormonal treatments have become more frequent. The survival rate has improved steadily during the past 5 decades. The 10-year crude overall survival rate improved from 61% before 1960 to 83% in the 1990s.<br />Conclusions: The survival rate of Japanese women with breast cancer has dramatically improved during the past 5 decades.
- Subjects :
- Adult
Aged
Aged, 80 and over
Antineoplastic Agents therapeutic use
Antineoplastic Agents, Hormonal therapeutic use
Breast Neoplasms pathology
Breast Neoplasms surgery
Combined Modality Therapy
Female
Humans
Japan epidemiology
Lymph Node Excision statistics & numerical data
Lymphatic Metastasis
Mastectomy methods
Menopause
Middle Aged
Neoplasm Staging
Prognosis
Survival Rate
Time Factors
Breast Neoplasms mortality
Breast Neoplasms therapy
Mastectomy statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 0368-2811
- Volume :
- 34
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Japanese journal of clinical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 15371463
- Full Text :
- https://doi.org/10.1093/jjco/hyh076