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Detection of Rickettsia africae in patients and ticks along the coastal region of Cameroon.
- Source :
-
The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2004 Sep; Vol. 71 (3), pp. 363-6. - Publication Year :
- 2004
-
Abstract
- Rickettsia africae was identified in seven (6%) of 118 patients with acute fevers of unknown etiology proven not to be malaria or typhoid fever from clinics along the coastal region of Cameroon by polymerase chain reaction (PCR) amplification and sequencing of the citrate synthase (gltA) and outer membrane protein A (ompA) genes of Rickettsia. The majority (71%) of the patients were female. Clinical manifestations included fever (100%), headache (71%), myalgia (71%), arthralgia (43%), pulmonary involvement (29%), and diffuse rash (14%). Moreover, R. africae was detected by PCR amplification and sequence analysis of the gltA and ompA genes in 62 (75%) of 83 adult Amblyomma variegatum ticks collected from cattle in the same region. These results confirm the presence of a previously unrecognized infectious disease in the indigenous Cameroonian population, as well as extend the established range of R. africae.
- Subjects :
- Adult
Animals
Bacterial Outer Membrane Proteins genetics
Cameroon
Citrate (si)-Synthase genetics
DNA, Bacterial genetics
Female
Humans
Male
Middle Aged
Polymerase Chain Reaction methods
Prevalence
Rickettsia genetics
Rickettsia Infections complications
Rickettsia Infections diagnosis
Sequence Analysis, Protein methods
Arachnid Vectors microbiology
Fever of Unknown Origin microbiology
Rickettsia isolation & purification
Rickettsia Infections microbiology
Ticks microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9637
- Volume :
- 71
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The American journal of tropical medicine and hygiene
- Publication Type :
- Academic Journal
- Accession number :
- 15381820