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Linkage analyses of four regions previously implicated in dyslexia: confirmation of a locus on chromosome 15q.
- Source :
-
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics [Am J Med Genet B Neuropsychiatr Genet] 2004 Nov 15; Vol. 131B (1), pp. 67-75. - Publication Year :
- 2004
-
Abstract
- Dyslexia is a common, complex disorder, which is thought to have a genetic component. There have been numerous reports of linkage to several regions of the genome for dyslexia and continuous dyslexia-related phenotypes. We attempted to confirm linkage of continuous measures of (1) accuracy and efficiency of phonological decoding; and (2) accuracy of single word reading (WID) to regions on chromosomes 2p, 6p, 15q, and 18p, using 111 families with a total of 898 members. We used both single-marker and multipoint variance components linkage analysis and Markov Chain Monte Carlo (MCMC) joint segregation and linkage analysis for initial inspection of these regions. Positive results were followed with traditional parametric lod score analysis using a model estimated by MCMC segregation analysis. No positive linkage signals were found on chromosomes 2p, 6p, or 18p. Evidence of linkage of WID to chromosome 15q was found with both methods of analysis. The maximum single-marker parametric lod score of 2.34 was obtained at a distance of 3 cM from D15S143. Multipoint analyses localized the putative susceptibility gene to the interval between markers GATA50C03 and D15S143, which falls between a region implicated in a recent genome screen for attention-deficit/hyperactivity disorder, and DYX1C1, a candidate gene for dyslexia. This apparent multiplicity of linkage signals in the region for developmental disorders may be the result of errors in map and/or model specification obscuring the pleiotropic effect of a single gene on different phenotypes, or it may reflect the presence of multiple genes.
- Subjects :
- Cytoskeletal Proteins
Dyslexia pathology
Family Health
Female
Genetic Markers
Genetic Predisposition to Disease genetics
Genotype
Humans
Lod Score
Male
Microsatellite Repeats
Monte Carlo Method
Nerve Tissue Proteins genetics
Nuclear Proteins genetics
Phenotype
Chromosomes, Human, Pair 15 genetics
Dyslexia genetics
Genetic Linkage
Subjects
Details
- Language :
- English
- ISSN :
- 1552-4841
- Volume :
- 131B
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 15389770
- Full Text :
- https://doi.org/10.1002/ajmg.b.30018