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Macrophages, pathology and parasite persistence in experimental visceral leishmaniasis.
- Source :
-
Trends in parasitology [Trends Parasitol] 2004 Nov; Vol. 20 (11), pp. 524-30. - Publication Year :
- 2004
-
Abstract
- Many infectious diseases are associated with parasite persistence, often restricted to certain tissue sites, yet the determinants of such persistence are poorly understood. Infection with the protozoan parasite Leishmania donovani has proved a useful experimental tool to address how immune responses can be differentially effective in clearing parasites from different tissues and, conversely, it might also provide a good model for understanding the basis of parasite persistence. This article reviews recent studies on the determinants and consequences of persistent parasite infection in the spleen and suggest that some of the messages to emerge could have important implications for the study of a broad range of infectious diseases.
- Subjects :
- Animals
Host-Parasite Interactions immunology
Humans
Leishmania donovani pathogenicity
Leishmaniasis, Visceral immunology
Leishmaniasis, Visceral pathology
Life Cycle Stages
Liver parasitology
Liver pathology
Macrophages immunology
Macrophages parasitology
Spleen parasitology
Spleen pathology
Leishmania donovani immunology
Leishmaniasis, Visceral parasitology
Subjects
Details
- Language :
- English
- ISSN :
- 1471-4922
- Volume :
- 20
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Trends in parasitology
- Publication Type :
- Academic Journal
- Accession number :
- 15471704
- Full Text :
- https://doi.org/10.1016/j.pt.2004.08.009