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[Identification of G6PD gene variants from Hakka population in Guangdong province].
- Source :
-
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics [Zhonghua Yi Xue Yi Chuan Xue Za Zhi] 2004 Oct; Vol. 21 (5), pp. 448-51. - Publication Year :
- 2004
-
Abstract
- Objective: Studying on G6PD polymorphism from Hakka population in Guangdong province.<br />Methods: Identifying the variants of G6PD gene and determining the frequencies respectively with the use of amplified refractory mutation system(ARMS), polymerase chain reaction-single strand conformation polymorphism(PCR-SSCP) and ABI 3100 DNA sequencing technologies.<br />Results: Mutations of G6PD gene in cDNA 1388 (G-->A), 1376 (G-->T), 95 (A-->G), 392 (G-->T), 1024 (C-->T), 1311 (C-->T) have been found.<br />Conclusion: G6PD cDNA 1388 (G-->A), 1376 (G-->T), 95(A--> G), 392 (G-->T), 1024 (C-->T) and 1311 (C-->T) accompanied with intron 11 (93 T-->C) are the common mutations in Chinese population. cDNA 1388 (G-->A), cDNA 1376 (G-->T) are the most popular G6PD gene variants in Hakka population. In this study, no new type of G6PD gene mutation was found in the Hakkas of Guangdong.
- Subjects :
- Asian People genetics
China
DNA Mutational Analysis
Glucosephosphate Dehydrogenase Deficiency ethnology
Humans
Introns
Polymerase Chain Reaction
Sequence Analysis, DNA
Glucosephosphate Dehydrogenase genetics
Glucosephosphate Dehydrogenase Deficiency genetics
Polymorphism, Single Nucleotide
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1003-9406
- Volume :
- 21
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
- Publication Type :
- Academic Journal
- Accession number :
- 15476167