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Iron catalysed assembly of an asymmetric mixed-ligand triple helicate.
- Source :
-
Dalton transactions (Cambridge, England : 2003) [Dalton Trans] 2004 Oct 21 (20), pp. 3342-6. Date of Electronic Publication: 2004 Sep 07. - Publication Year :
- 2004
-
Abstract
- The 2-pyridinecarbaldehyde isonicotinoyl hydrazone (HPCIH) family of ligands are typically tridentate N,N,O chelators that exhibit very high in vitro activity in mobilizing intracellular Fe and are promising candidates for the treatment of Fe overload diseases. Complexation of ferrous perchlorate with HPCIH in MeCN solution gives the expected six-coordinate complex Fe(II)(PCIH)(2). However, complexation of Fe(II) with 2-pyridinecarbaldehyde picolinoyl hydrazone (HPCPH, an isomer of HPCIH) under the same conditions leads to spontaneous assembly of an unprecedented asymmetric, mixed-ligand dinuclear triple helical complex Fe(II)(2)(PCPH)(2)(PPH), where PPH(2-) is the dianion of bis(picolinoyl)hydrazine. The X-ray crystal structure of this complex shows that each ligand binds simultaneously to both metal centres in a bidentate fashion. The dinuclear complex exhibits two well separated and totally reversible Fe(III/II) redox couples as shown by cyclic voltammetry in MeCN solution.
Details
- Language :
- English
- ISSN :
- 1477-9226
- Issue :
- 20
- Database :
- MEDLINE
- Journal :
- Dalton transactions (Cambridge, England : 2003)
- Publication Type :
- Academic Journal
- Accession number :
- 15483720
- Full Text :
- https://doi.org/10.1039/B408781J