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Quantitation of HIV-1 proviral DNA in cells from cerebrospinal fluid.
- Source :
-
Journal of acquired immune deficiency syndromes [J Acquir Immune Defic Syndr (1988)] 1992; Vol. 5 (4), pp. 405-8. - Publication Year :
- 1992
-
Abstract
- The number of proviral copies in the cerebrospinal fluid of 13 patients in various stages of HIV-1 infection was determined using the polymerase chain reaction. HIV-1 proviral DNA was detected at a median value of 1 provirus per 300 cells with a range from 1 per 20 to 1 per 2,400 cells and a mean value of 1 provirus per 570 cells. Interestingly, this indicates a higher proportion of infected cells in cerebrospinal fluid than is reported to be the case for blood mononuclear cells. However, a clear correlation of these findings to the CDC stage or to neurologic complications was not obvious.
- Subjects :
- Acquired Immunodeficiency Syndrome cerebrospinal fluid
Acquired Immunodeficiency Syndrome genetics
Acquired Immunodeficiency Syndrome microbiology
Base Sequence
DNA Replication
DNA, Viral biosynthesis
DNA, Viral chemistry
Humans
Molecular Sequence Data
Polymerase Chain Reaction
Subcellular Fractions microbiology
DNA, Viral cerebrospinal fluid
HIV-1 genetics
Proviruses genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0894-9255
- Volume :
- 5
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of acquired immune deficiency syndromes
- Publication Type :
- Academic Journal
- Accession number :
- 1548576