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Diagnosis and treatment of zinc poisoning in a dog.
- Source :
-
Veterinary and human toxicology [Vet Hum Toxicol] 2004 Oct; Vol. 46 (5), pp. 272-5. - Publication Year :
- 2004
-
Abstract
- Acute zinc poisoning has been observed in dogs following the ingestion of metallic zinc objects. A 1 1/2-y-old female miniature bull terrier exhibiting anorexia, vomiting, depression, fever (39.9 C), icterus and intravascular hemolysis was diagnosed with acute zinc poisoning. Anemia, Heinz body production, azotemia and bilirubinemia were also evident. Abnormal pancreatic, hepatic and renal functions were also apparent. A radio opaque object was observed in the stomach. Based upon an elevated plasma zinc level of 28.6 ppm, a tentative diagnosis of zinc poisoning was made. Following surgical removal of the metallic zinc object, a blood transfusion and fluid therapy were given to restore the normal blood volume. Heparin, Cephazolin and Raniditine were also given, although chelation therapy was not provided. Zinc levels in the plasma declined in a steady fashion (half-life = 7.6 d). Complications, such as disseminated intravascular coagulation, chronic pancreatitis, renal or hepatic failure, were not observed. By 20 d post surgery, only mild elevation of liver enzymes was evident. Measurements of the half-life of zinc may provide a useful indication of prognosis and the success of treatment.
- Subjects :
- Animals
Anorexia etiology
Anorexia veterinary
Anticoagulants administration & dosage
Blood Transfusion veterinary
Cefazolin therapeutic use
Diagnosis, Differential
Dogs
Female
Foreign Bodies surgery
Heparin administration & dosage
Histamine H2 Antagonists therapeutic use
Ranitidine therapeutic use
Sleep Stages
Zinc pharmacokinetics
Foreign Bodies veterinary
Poisoning therapy
Poisoning veterinary
Zinc poisoning
Subjects
Details
- Language :
- English
- ISSN :
- 0145-6296
- Volume :
- 46
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Veterinary and human toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 15487653