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Persistent HPV infection in postmenopausal age women.
- Source :
-
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics [Int J Gynaecol Obstet] 2004 Nov; Vol. 87 (2), pp. 131-7. - Publication Year :
- 2004
-
Abstract
- Objective: Persistence of human papillomavirus (HPV) is associated with an increased risk of developing cervical SIL and cancer in young women. Because this association in older, postmenopausal age women has received little attention, we evaluated persistence of HPV among women in this age group.<br />Methods: Women (n=105) ages 45-64 were examined annually for 7 years to evaluate HPV in cervical cytologic specimens. PCR, dot blot hybridization and DNA sequencing were used to detect HPV types.<br />Results: The cumulative prevalence of HPV was 34%, and 24% had HPV high-risk oncogenic types which are associated with genital cancers. The most common oncogenic types were HPV-16 (72%) and HPV-31 (16%). The persistence rate of HPV infection was 16%. No specific risk factors were associated with repeat viral positivity.<br />Conclusion: Postmenopausal women are infected with persistent oncogenic HPV at a substantial rate, supporting the need for continued screening in postmenopausal women to detect preneoplastic genital lesions.
- Subjects :
- Age Factors
Aged
DNA, Viral analysis
Estrogen Replacement Therapy
Female
Humans
Iowa epidemiology
Middle Aged
Papillomaviridae genetics
Papillomavirus Infections pathology
Papillomavirus Infections prevention & control
Papillomavirus Infections virology
Polymerase Chain Reaction
Postmenopause
Prevalence
Randomized Controlled Trials as Topic
Risk Factors
Tumor Virus Infections pathology
Tumor Virus Infections prevention & control
Tumor Virus Infections virology
Vaginal Smears statistics & numerical data
Papillomaviridae isolation & purification
Papillomavirus Infections epidemiology
Tumor Virus Infections epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 0020-7292
- Volume :
- 87
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
- Publication Type :
- Academic Journal
- Accession number :
- 15491557
- Full Text :
- https://doi.org/10.1016/j.ijgo.2004.07.013