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Rotavirus serotype G9P[8] and acute gastroenteritis outbreak in children, Northern Australia.
- Source :
-
Emerging infectious diseases [Emerg Infect Dis] 2004 Sep; Vol. 10 (9), pp. 1593-600. - Publication Year :
- 2004
-
Abstract
- During 2001, an outbreak of severe acute gastroenteritis swept through Central and northern Australia and caused serious disruption to health services. We tracked and characterized the rotavirus strain implicated in the outbreak. Comparison of the electropherotypes of outbreak samples suggested that one G9P[8] strain was likely responsible for the outbreak. Samples were obtained from geographically distinct regions of Australia where the epidemic had occurred. The outbreak strains showed identical nucleotide sequences in genes encoding three rotavirus proteins, VP7, VP8, and NSP4, but they were distinct from G9P[8] strains isolated in previous years. Several of the amino acid substitutions on the VP7 and NSP4 proteins were identified in regions known to influence function and may have contributed to the emergence and increased dominance of the outbreak strains. Rotavirus serotype surveillance should continue with methods capable of identifying new and emerging types.
- Subjects :
- Antigens, Viral genetics
Australia epidemiology
Capsid Proteins genetics
Child
Female
Humans
Male
Molecular Epidemiology
Rotavirus classification
Rotavirus isolation & purification
Rotavirus Infections virology
Sequence Homology, Amino Acid
Serotyping
Time Factors
Disease Outbreaks
Gastroenteritis virology
Rotavirus genetics
Rotavirus Infections epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1080-6040
- Volume :
- 10
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Emerging infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 15498161
- Full Text :
- https://doi.org/10.3201/eid1009.040040