[Study on the potentiation of bone marrow mesenchymal stem cells involved in sebaceous duct formation].

Objective: To investigate the feasibility of differentiation of bone marrow mesenchymal stem cells (MSCs) into skin appandence.
Methods: Porcine MSCs were isolated from porcine marrow and grown in vitro. After labeling with BrdU, MSCs were engrafted to porcine skin. At 1, 2, 4 weeks after the transplantation, immunohistochemical examinations were carried out to detect the positive staining of BrdU and cytokeratin.
Results: A few sebaceous duct cells, which expressed cytokeratin, were also BrdU positive, and these cells were considered may to be transplanted MSCs-derived cells.
Conclusion: Porcine MSCs might have the potential to differentiated into sebaceous duct cells in skin.