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Peroxisome proliferator-activated receptor gamma gene polymorphism is associated with serum triglyceride levels and body mass index in Japanese type 2 diabetic patients.
- Source :
-
Journal of clinical laboratory analysis [J Clin Lab Anal] 2004; Vol. 18 (6), pp. 317-21. - Publication Year :
- 2004
-
Abstract
- Peroxisome proliferator-activated receptor gamma (PPARgamma) controls adipocyte differentiation and regulates lipid and glucose homeostasis. Therefore, the PPARgamma gene may affect insulin sensitivity and resistance. We analyzed the relationship between C/T exon 6 polymorphism of the PPARgamma gene and various clinical parameters in type 2 diabetic patients. There were no significant differences in the frequencies of genotype and allele between diabetic patients with and without nephropathy. Diabetic patients were divided into two groups: patients bearing at least one T allele (CT/TT), and patients with no T allele (CC). Levels of serum triglyceride and body mass index (BMI) were significantly higher in the CT/TT genotype group than in the CC genotype group. Since obesity affects insulin resistance, the diabetic patients were also divided into two groups: those with a BMI of <23, and those with a BMI of >23. In patients with a BMI of <23, there was no significant change in the levels of glycosylated hemoglobin A1c (HbA1c) between the CC and CT/TT genotype groups. However, in patients with a BMI of >23, HbA1c levels were significantly higher in the CT/TT genotype group than in the CC genotype group. It appears that the CT/TT genotype with PPARgamma gene polymorphism may contribute to higher BMI and higher serum triglyceride and HbA1c levels in Japanese type 2 diabetic patients.<br /> ((c) 2004 Wiley-Liss, Inc.)
- Subjects :
- Aged
Asian People
Body Mass Index
Diabetes Mellitus, Type 2 complications
Diabetic Neuropathies etiology
Female
Gene Frequency
Humans
Insulin Resistance genetics
Japan
Male
Middle Aged
Obesity genetics
Diabetes Mellitus, Type 2 genetics
Diabetic Neuropathies genetics
PPAR gamma genetics
Polymorphism, Genetic genetics
Triglycerides blood
Subjects
Details
- Language :
- English
- ISSN :
- 0887-8013
- Volume :
- 18
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of clinical laboratory analysis
- Publication Type :
- Academic Journal
- Accession number :
- 15543562
- Full Text :
- https://doi.org/10.1002/jcla.20045