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Serologic evidence for exposure to simian virus 40 in North American zoo workers.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2004 Dec 15; Vol. 190 (12), pp. 2065-9. Date of Electronic Publication: 2004 Nov 16. - Publication Year :
- 2004
-
Abstract
- Some laboratories have detected DNA from the macaque polyomavirus simian virus 40 (SV40) in human tumors, but possible routes of infection remain unknown. In the present study, an enzyme immunoassay using viruslike particles (VLPs) was used to test 254 zoo workers for antibodies to SV40; 25 zoo workers with direct contact with nonhuman primates and 15 other zoo workers (23% vs. 10%, respectively; P=.01) were seropositive for SV40. Additionally, SV40 seroreactivity confirmed by competitive-inhibition experiments (i.e., blocked by addition of SV40 VLPs but not by VLPs for BK virus or JC virus, which are related human polyomaviruses) was increased in zoo workers with direct contact with nonhuman primates (10% vs. 3%, respectively; P=.04). SV40 seroreactivity therefore may reflect zoonotic exposure.
- Subjects :
- Animals
Animals, Zoo virology
BK Virus isolation & purification
Capsid
Humans
Immunoenzyme Techniques
JC Virus isolation & purification
North America epidemiology
Polyomavirus Infections epidemiology
Primates virology
Seroepidemiologic Studies
Tumor Virus Infections epidemiology
Occupational Exposure
Simian virus 40 isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 190
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 15551203
- Full Text :
- https://doi.org/10.1086/425997