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CD8+ T-cell response against MUC1-derived peptides in gastrointestinal cancer survivors.
- Source :
-
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2005 Aug; Vol. 54 (8), pp. 750-8. Date of Electronic Publication: 2004 Dec 22. - Publication Year :
- 2005
-
Abstract
- The tumor-associated antigens CEA, MUC1 and Her2/neu are broadly expressed in gastrointestinal tumors, and are attractive candidates for targeting by T-cell-based immunotherapy. However, little is known about the natural cytotoxic T-cell response of patients suffering from colorectal or gastric carcinoma against these three as well as other antigens. Using a quantitative reverse transcription-polymerase chain reaction-based assay for IFN-gamma, we analyzed the CD8+ T-cell repertoire present in the blood of HLA-A2+ gastrointestinal tumor survivors against five known epitopes derived from CEA, MUC1 and Her2/neu. The results show that most of the patients (16 from 22 tested) have detectable, peripheral CD8+ T cells directed against at least one of these three proteins. Interestingly, the majority of these patients reacts to the two MUC1-derived HLA-A*0201 epitopes tested (14 from 16), demonstrating that this protein represents one dominant target for CD8+ T cells in gastrointestinal cancer.
Details
- Language :
- English
- ISSN :
- 0340-7004
- Volume :
- 54
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Cancer immunology, immunotherapy : CII
- Publication Type :
- Academic Journal
- Accession number :
- 15614528
- Full Text :
- https://doi.org/10.1007/s00262-004-0640-7