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TTF-1 and surfactant-B as co-adjuvants in the diagnosis of lung adenocarcinoma and pleural mesothelioma.
- Source :
-
Annals of diagnostic pathology [Ann Diagn Pathol] 2004 Dec; Vol. 8 (6), pp. 337-41. - Publication Year :
- 2004
-
Abstract
- Primary lung adenocarcinomas and metastatic adenocarcinomas may show a great morphologic resemblance to malignant mesothelioma. There are numerous immunohistochemical markers being used, but none of them were proved to be effective enough to reach a certain diagnosis. The current study was performed to evaluate the utility of thyroid transcription factor-1 (TTF-1) and surfactant protein-B (SP-B) expression in the differential diagnosis between lung adenocarcinomas and pleural mesotheliomas. In this retrospective study, TTF-1 and SP-B were applied to 30 cases with adenocarcinoma and 15 cases with pleural mesothelioma, immunohistochemically, using an avidin-biotin detection system. Twenty percent of adenocarcinomas and 13.3% of pleural mesothelioma stained positive for SP-B. TTF-1 stained 24 of the 30 adenocarcinomas (80%) and none of the 15 mesotheliomas (0%). TTF-1 positivity in adenocarcinomas was found to be statistically significant, while SP-B had no important practical value either used alone or in combination with TTF-1. There was no statistically significant correlation between the differentiation level of adenocarcinomas and TTF-1 staining pattern. In conclusion, we believe that TTF-1 may be helpful in distinguishing lung adenocarcinoma from pleural mesothelioma.
- Subjects :
- Adenocarcinoma metabolism
Biomarkers, Tumor metabolism
Diagnosis, Differential
Humans
Lung Neoplasms metabolism
Mesothelioma metabolism
Pleural Neoplasms metabolism
Reproducibility of Results
Retrospective Studies
Thyroid Nuclear Factor 1
Adenocarcinoma diagnosis
Lung Neoplasms diagnosis
Mesothelioma diagnosis
Nuclear Proteins metabolism
Pleural Neoplasms diagnosis
Pulmonary Surfactant-Associated Protein B metabolism
Transcription Factors metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1092-9134
- Volume :
- 8
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Annals of diagnostic pathology
- Publication Type :
- Academic Journal
- Accession number :
- 15614737
- Full Text :
- https://doi.org/10.1053/j.anndiagpath.2004.08.003