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Genotoxicity studies on dietary diacylglycerol (DAG) oil.
- Source :
-
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2005 Feb; Vol. 43 (2), pp. 253-60. - Publication Year :
- 2005
-
Abstract
- Dietary diacylglycerol (DAG) oil is an edible oil enriched in DAG (more than 80%). A recent investigation indicated that DAG oil or its components may have beneficial effects on the prevention and management of obesity. We evaluated the genotoxic potential of DAG oil using standard genotoxicity tests. Bacterial reverse mutation assay (Ames test), the chromosomal aberration assay in cultured Chinese hamster lung cells (CHL/IU), and a bone marrow micronucleus assay in ICR CD mice were employed in the present study. In addition we have tested the possibility that genotoxic substances may be formed during cooking, heated DAG oil (HDG) was prepared by batch frying potato slices in the oil at 180 degrees C for 8 h/day for three consecutive days. Therefore, genotoxicity tests were also performed on HDG. Results obtained did not show any genotoxic effect on either unheated DAG oil (UDG) or HDG. We conclude that there are no safety concerns on the genotoxicity of DAG oil under the conditions for normal use.
- Subjects :
- Animals
Bone Marrow drug effects
Cricetinae
Cricetulus
Dietary Fats administration & dosage
Dose-Response Relationship, Drug
Hot Temperature
Lung cytology
Lung drug effects
Mice
Mice, Inbred ICR
Micronucleus Tests
Microsomes, Liver drug effects
Obesity diet therapy
Safety
Salmonella typhimurium drug effects
Salmonella typhimurium genetics
Chromosome Aberrations drug effects
Cooking methods
Dietary Fats toxicity
Diglycerides administration & dosage
Diglycerides toxicity
Mutagenicity Tests methods
Subjects
Details
- Language :
- English
- ISSN :
- 0278-6915
- Volume :
- 43
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- Publication Type :
- Academic Journal
- Accession number :
- 15621338
- Full Text :
- https://doi.org/10.1016/j.fct.2004.10.001