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[Clinical significance of survivin expression in colorectal cancer and its relationship with cell apoptosis and angiogenesis].
- Source :
-
Ai zheng = Aizheng = Chinese journal of cancer [Ai Zheng] 2005 Jan; Vol. 24 (1), pp. 116-20. - Publication Year :
- 2005
-
Abstract
- Background & Objective: Expression of survivin, an apoptosis suppressor gene, in colorectal cancer(CRC), and its relationship with pathologic factors, cell apoptosis, and angiogenesis are unclear. This study aimed to investigate the effect of survivin on cell apoptosis, and its relation with angiogenesis, and to further explore the effects of survivin on development and prognosis of CRC.<br />Methods: Protein expression of survivin, and vascular endothelial growth factor (VEGF) in 91 specimens of CRC was detected by immunohistochemistry, apoptosis index (AI) of tumor cells was detected by TUNEL method.<br />Results: Positive rate of survivin in CRC with distant metastasis was 56.0% (14/25), significantly higher than that in CRC without metastasis (48.5%, 32/66) (P<0.05); and that in 5-year survival patients(42.9%,30/70) was lower than that in patients died within 5 years (76.2%,16/21) (P<0.01). The average survival time of patients with positive expression of survivin was 91.3 months, and that of patients with negative expression of survivin was 116.4 months; 5-year survival rate of the former (65.2%, 30/46) was significantly lower than that of the latter (88.9%, 40/45) (P<0.01). The average AI of patients with positive expression of survivin was lower than that of patients with negative expression of survivin [(0.74+/-0.19)% vs. (1.07+/-0.24)%, P<0.01]; the expression of survivin significantly correlated with that of VEGF (pearson: 0.721).<br />Conclusion: Survivin may promote metastasis, and affect prognosis of CRC through inhibiting cell apoptosis, and regulating angiogenesis of CRC.
- Subjects :
- Adult
Aged
Aged, 80 and over
Colonic Neoplasms pathology
Female
Follow-Up Studies
Humans
Inhibitor of Apoptosis Proteins
Liver Neoplasms metabolism
Liver Neoplasms secondary
Lung Neoplasms metabolism
Lung Neoplasms secondary
Lymphatic Metastasis
Male
Middle Aged
Neoplasm Staging
Prognosis
Rectal Neoplasms pathology
Survival Rate
Survivin
Vascular Endothelial Growth Factor A metabolism
Apoptosis
Colonic Neoplasms metabolism
Microtubule-Associated Proteins metabolism
Neoplasm Proteins metabolism
Neovascularization, Pathologic
Rectal Neoplasms metabolism
Subjects
Details
- Language :
- Chinese
- Volume :
- 24
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Ai zheng = Aizheng = Chinese journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 15642214