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Critical role of heme oxygenase-1 in Foxp3-mediated immune suppression.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2005 Feb 25; Vol. 327 (4), pp. 1066-71. - Publication Year :
- 2005
-
Abstract
- Foxp3, which encodes the transcription factor scurfin, is indispensable for the development and function of CD4(+)CD25(+) regulatory T cells (Treg). Recent data suggest conversion of peripheral CD4(+)CD25(-) nai ve T cells to CD4(+)CD25(+) Treg by acquisition of Foxp3 through costimulation with TCR and TGF-beta or forced expression of the gene. One critical question is how Foxp3 causes T cells to become regulatory. In the present work, we demonstrate that Foxp3 can induce heme oxygenase-1 (HO-1) expression and subsequently such regulatory phenotypes as the suppression of nontransfected cells in a cell-cell contact-dependent manner as well as impaired proliferation and production of cytokines upon stimulation in Jurkat T cells. Moreover, we confirm the expression of both Foxp3 and HO-1 in peripheral CD4(+)CD25(+) Treg and suppressive function of the cells are relieved by the inhibition of HO-1 activity. In summary, we demonstrate that Foxp3 induces HO-1 expression and HO-1 engages in Foxp3-mediated immune suppression.
- Subjects :
- CD4-Positive T-Lymphocytes immunology
Cell Proliferation
DNA-Binding Proteins genetics
DNA-Binding Proteins immunology
Forkhead Transcription Factors
Gene Expression Regulation, Leukemic
Heme Oxygenase (Decyclizing) genetics
Heme Oxygenase-1
Humans
Immune Tolerance immunology
Jurkat Cells
Membrane Proteins
Receptors, Interleukin-2 immunology
Transfection
DNA-Binding Proteins metabolism
Heme Oxygenase (Decyclizing) metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0006-291X
- Volume :
- 327
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 15652505
- Full Text :
- https://doi.org/10.1016/j.bbrc.2004.12.106