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Non-peptidic small molecule inhibitors of XIAP.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2005 Feb 01; Vol. 15 (3), pp. 771-5. - Publication Year :
- 2005
-
Abstract
- Non-peptidic small molecule SMAC mimetics were designed and synthesized that bind to the BIR3 domain of XIAP using structure-based design. Substituted five-membered heterocycles such as thiazoles and imidazoles were identified that serve as replacements for peptide fragments of the lead.
- Subjects :
- Binding Sites
Drug Design
Heterocyclic Compounds pharmacology
Humans
Imidazoles chemical synthesis
Imidazoles pharmacology
Ligands
Magnetic Resonance Spectroscopy
Structure-Activity Relationship
Thiazoles chemical synthesis
Thiazoles pharmacology
X-Linked Inhibitor of Apoptosis Protein
Heterocyclic Compounds chemical synthesis
Proteins antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 15
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 15664855
- Full Text :
- https://doi.org/10.1016/j.bmcl.2004.11.010