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[Malignant germ cell tumours. Multicenter prospective trial in Polish Pediatric Group for Solid Tumours (years 1998-2000)].
- Source :
-
Przeglad lekarski [Przegl Lek] 2004; Vol. 61 Suppl 2, pp. 29-32. - Publication Year :
- 2004
-
Abstract
- Unlabelled: Germ cell tumors constitute about 3% of all pediatric malignancies. Since 1998 the multicenter trial was initiated in Poland.<br />Material and Methods: 95 children (aged from 1 month to 17 years--mean 9.2 years) were registered. There were 38 boys and 57 girls. Diagnosis was made on histopathological examination in 88% patients (pts) and in 12% was established on imaging and biochemical findings (elevated AFP). Mixed germ cell tumor and yolk sac tumor prevelaged. AFP was elevated in 72% pts; in 26% it was over 15.000. Primary tumor was localized in gonads (59%) and in sacrococcygeal region (30%). Following disease stages were identified: I and II--41% pts, III--34%, IV--25%. All patients were treated according to French TGM'95 protocol. 43 belonged to high risk and 52 to standard risk group. 77 children completed therapy, 15 continue treatment and 3 were lost from follow-up.<br />Results: Among children who were off therapy, 70 (91%) are alive in a complete remission (second remission in 3 cases). Survival in high risk group is 89%, while in standard risk group is 93%. Median time of follow-up is 31 months from the beginning of treatment and 25 months after completion of therapy. 7 children died; all had progressive disease.<br />Conclusion: The outcome of malignant germ cell tumors treatment in Poland is favourable and comparable to results showed by other study groups in the world.
- Subjects :
- Adolescent
Child
Child, Preschool
Endodermal Sinus Tumor drug therapy
Endodermal Sinus Tumor surgery
Female
Humans
Infant
Male
Neoplasm Invasiveness
Neoplasm Staging
Neoplasms, Germ Cell and Embryonal metabolism
Neoplasms, Germ Cell and Embryonal pathology
Poland
Prospective Studies
Survival Analysis
Time Factors
Treatment Outcome
alpha-Fetoproteins metabolism
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Neoplasms, Germ Cell and Embryonal drug therapy
Neoplasms, Germ Cell and Embryonal surgery
Subjects
Details
- Language :
- Polish
- ISSN :
- 0033-2240
- Volume :
- 61 Suppl 2
- Database :
- MEDLINE
- Journal :
- Przeglad lekarski
- Publication Type :
- Academic Journal
- Accession number :
- 15686043