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alpha-Internexin immunoreactivity reflects variable neuronal vulnerability in Alzheimer's disease and supports the role of the beta-amyloid plaques in inducing neuronal injury.
- Source :
-
Neurobiology of disease [Neurobiol Dis] 2005 Mar; Vol. 18 (2), pp. 286-95. - Publication Year :
- 2005
-
Abstract
- This study investigated the role of alpha-internexin in the neuronal alterations associated with beta-amyloid plaque formation in Alzheimer's disease (AD). Cortical neurons could be defined by their variable content of neurofilament (NF) triplet and alpha-internexin proteins, with a distinct population of supragranular pyramidal cells containing alpha-internexin alone. Both NF triplet and alpha-internexin were localized to reactive axonal structures in physically damaged neurons in experimental trauma models. Similarly, NF triplet and alpha-internexin immunoreactive neurites were localized to plaques densely packed with beta-amyloid fibrils in preclinical AD cases, indicating that certain plaques may cause structural injury or impediment of local axonal transport. However, alpha-internexin, and not NF triplet, ring-like reactive neurites were present in end-stage AD cases, indicating the relatively late involvement of neurons that selectively contain alpha-internexin. These results implicate the expression of specific intermediate filament proteins in a distinct hierarchy of differential neuronal vulnerability to AD.
- Subjects :
- Aged
Aged, 80 and over
Alzheimer Disease pathology
Amyloid beta-Peptides metabolism
Animals
Brain Injuries pathology
Causality
Cerebral Cortex pathology
Disease Models, Animal
Female
Humans
Immunohistochemistry
Intermediate Filament Proteins
Male
Middle Aged
Nerve Degeneration metabolism
Nerve Degeneration pathology
Neurites metabolism
Neurites pathology
Neurofilament Proteins metabolism
Neurons pathology
Plaque, Amyloid pathology
Pyramidal Cells metabolism
Pyramidal Cells pathology
Rats
Rats, Wistar
Alzheimer Disease metabolism
Brain Injuries metabolism
Carrier Proteins metabolism
Cerebral Cortex metabolism
Neurons metabolism
Plaque, Amyloid metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0969-9961
- Volume :
- 18
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Neurobiology of disease
- Publication Type :
- Academic Journal
- Accession number :
- 15686957
- Full Text :
- https://doi.org/10.1016/j.nbd.2004.10.001