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Relationship of hepatocellular carcinoma to soya food consumption: a cohort-based, case-control study in Japan.
- Source :
-
International journal of cancer [Int J Cancer] 2005 Jun 10; Vol. 115 (2), pp. 290-5. - Publication Year :
- 2005
-
Abstract
- To determine if the risk of hepatocellular carcinoma (HCC) is reduced by consumption of soya foods, we conducted a case-control study within a cohort of Japanese A-bomb survivors. We compared the prediagnosis consumption of isoflavone-rich miso soup and tofu to HCC risk, adjusting for hepatitis B (HBV) and C (HCV) viral infections, the major HCC risk factors in this population. The study included 176 pathologist-confirmed cases of HCC diagnosed in 1964-1988 and 560 controls who died of diseases other than liver cancer. We examined dietary information collected at least 2 years before diagnosis or death and tissue-based measures of viral hepatitis. Using logistic regression, crude ORs were 0.5 (95% CI 0.29-0.95) and 0.5 (95% CI 0.20-0.99) for high vs. low miso soup and tofu intake, respectively. Adjusting for year of birth, sex, HBV, HCV and other factors, the OR for miso soup was unchanged at 0.5 (95% CI 0.14-1.55), and miso results were similar when ORs were recalculated separately for earlier and later birth cohorts to assess consistency of results. The adjusted OR for tofu was 0.9 (95% CI 0.20-3.51). We also found a statistically significant (p < 0.0001) interaction between sex and HCV, with risk of HCC being substantially higher for women. We conclude that consumption of miso soup and other soya foods may reduce HCC risk.<br /> (Copyright 2005 Wiley-Liss, Inc)
- Subjects :
- Carcinoma, Hepatocellular epidemiology
Carcinoma, Hepatocellular etiology
Case-Control Studies
Cohort Studies
Feeding Behavior
Hepacivirus isolation & purification
Hepatitis B complications
Hepatitis B epidemiology
Hepatitis B virus isolation & purification
Hepatitis C complications
Hepatitis C epidemiology
Humans
Japan
Liver Neoplasms epidemiology
Liver Neoplasms etiology
Risk Factors
Carcinoma, Hepatocellular diet therapy
Hepatitis B diet therapy
Hepatitis C diet therapy
Liver Neoplasms diet therapy
Soy Foods
Subjects
Details
- Language :
- English
- ISSN :
- 0020-7136
- Volume :
- 115
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 15688396
- Full Text :
- https://doi.org/10.1002/ijc.20897