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Modulation of osteoclast formation.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2005 Mar 18; Vol. 328 (3), pp. 739-45. - Publication Year :
- 2005
-
Abstract
- Osteoclasts are derived following the fusion of precursors of hematopoietic and myelomonocytic origin after appropriate stimulus, such as that afforded by RANKL and M-CSF. Thus the osteoclast can be considered as a specialized type of macrophage, and several of the factors that affect osteoclast formation also have affects upon macrophage differentiation. Inhibitors of osteoclast formation may perturb RANKL or M-CSF signalling or affect other signalling pathways. Several of these inhibitors are discussed with the view of their capacity to influence osteoclast differentiation, but not necessarily their activity.
- Subjects :
- Cell Differentiation physiology
Gene Expression Regulation physiology
Homeostasis physiology
Macrophages cytology
Macrophages physiology
RANK Ligand
Carrier Proteins metabolism
Cytokines metabolism
Hematopoietic Stem Cells cytology
Hematopoietic Stem Cells physiology
Membrane Glycoproteins metabolism
Osteoclasts cytology
Osteoclasts physiology
Signal Transduction physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0006-291X
- Volume :
- 328
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 15694408
- Full Text :
- https://doi.org/10.1016/j.bbrc.2004.11.076