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[p53 gene codon 72 polymorphism and susceptibility to keloid in Chinese population].

Authors :
Zhuo Y
Gao J
Luo S
Zeng W
Hu Z
Lu F
Zhao Y
Source :
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery [Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi] 2005 Jan; Vol. 19 (1), pp. 28-30.
Publication Year :
2005

Abstract

Objective: To investigate the relationship between p53 codon 72 polymorphism and susceptibility to keloid.<br />Methods: The p53 genotypes were detected by polymerase chain reaction-reverse dot blot (PCR-RDB) and DNA direct sequencing among 15 healthy controls and 15 patients with keloid.<br />Results: The frequency of the Pro allele (P = 0.035) and Pro/Pro genotype (P = 0.030) in patients was significantly higher than that in the controls. There was no significant difference in the frequency of Pro/Arg and Arg/Arg genotypes between patients and controls.<br />Conclusion: The p53 gene codon 72 polymorphism may play a role in susceptibility to keloid.

Details

Language :
Chinese
ISSN :
1002-1892
Volume :
19
Issue :
1
Database :
MEDLINE
Journal :
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
Publication Type :
Academic Journal
Accession number :
15704837