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[p53 gene codon 72 polymorphism and susceptibility to keloid in Chinese population].
- Source :
-
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery [Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi] 2005 Jan; Vol. 19 (1), pp. 28-30. - Publication Year :
- 2005
-
Abstract
- Objective: To investigate the relationship between p53 codon 72 polymorphism and susceptibility to keloid.<br />Methods: The p53 genotypes were detected by polymerase chain reaction-reverse dot blot (PCR-RDB) and DNA direct sequencing among 15 healthy controls and 15 patients with keloid.<br />Results: The frequency of the Pro allele (P = 0.035) and Pro/Pro genotype (P = 0.030) in patients was significantly higher than that in the controls. There was no significant difference in the frequency of Pro/Arg and Arg/Arg genotypes between patients and controls.<br />Conclusion: The p53 gene codon 72 polymorphism may play a role in susceptibility to keloid.
Details
- Language :
- Chinese
- ISSN :
- 1002-1892
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
- Publication Type :
- Academic Journal
- Accession number :
- 15704837