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[Primary research of pharmacological effects of PEC on mice].
- Source :
-
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2004 Jun; Vol. 29 (6), pp. 568-9, 593. - Publication Year :
- 2004
-
Abstract
- Objective: To study pharmacological effects of PEC (the oral liquid which consists of Panax quinquefolium, Epimedium brevicornum, Schisandra chinensis Bail and Cervus eplaphus) on mice.<br />Method: Experiments were carried out through swimming test, step-through, spontaneous activity and sleeping time.<br />Result: When 5-10 mL x kg(-1) of PEC was given orally for 7 days, it could prolong swimming duration of mice in water tank, and increase the tolerant ability against oxygen-deficiency. PEC could also improve cognitive-deficiency induced by taking off sleep with force in mice after given orally for 7 days. The PEC could increase the spontaneous activity in mice, antagonize the inhabitation induced by Valium, and shorten the sleeping time caused by sodium pentobarbital.<br />Conclusion: PEC has strong potential neuro-pharmacological activities such as anti-fatigue, improving cognitive-deficiency in mice.
- Subjects :
- Animals
Drug Combinations
Drugs, Chinese Herbal isolation & purification
Epimedium chemistry
Hypoxia drug therapy
Male
Mice
Panax chemistry
Pentobarbital pharmacology
Phytotherapy
Schisandra chemistry
Sleep drug effects
Swimming
Behavior, Animal drug effects
Drugs, Chinese Herbal pharmacology
Fatigue drug therapy
Memory Disorders drug therapy
Plants, Medicinal chemistry
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1001-5302
- Volume :
- 29
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- Publication Type :
- Academic Journal
- Accession number :
- 15706926