Back to Search
Start Over
Design, synthesis and biological evaluation of novel bicyclic beta-lactams as potential antimalarials.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2005 Mar 01; Vol. 15 (5), pp. 1371-3. - Publication Year :
- 2005
-
Abstract
- A series of bicyclic N-substituted and unsubstituted beta-lactams were synthesized and evaluated as targeted potential antimalarials. The compounds MNR4 and MNR5 were found to have highest potency against Plasmodium falciparum in vitro.
- Subjects :
- Animals
Drug Design
Drug Evaluation, Preclinical
Humans
Magnetic Resonance Spectroscopy
Molecular Structure
Parasitic Sensitivity Tests
Plasmodium falciparum isolation & purification
Structure-Activity Relationship
Antimalarials chemical synthesis
Antimalarials pharmacology
Bridged Bicyclo Compounds chemical synthesis
Bridged Bicyclo Compounds pharmacology
Plasmodium falciparum drug effects
beta-Lactams chemical synthesis
beta-Lactams pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 15
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 15713389
- Full Text :
- https://doi.org/10.1016/j.bmcl.2005.01.011