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[Studies on anti-hyperglycemic effect and its mechanism of Dendrobium candidum].
- Source :
-
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2004 Feb; Vol. 29 (2), pp. 160-3. - Publication Year :
- 2004
-
Abstract
- Objective: To study the anti-hyperglycemic effect and its mechanism of Dendrobium candidum (DC).<br />Method: Normal mice, adrenaline-induced hyperglycemic mice, streptozotocin-induced diabetic (STZ-DM) rats were used. The mechanisms of the anti-hyperglycemic action were studied with radio-immunoassay, immunohistochemical HRP-SPA stain, etc.<br />Result: DC could not obviously decrease the serum glucose concentrations and insulin levels in normal mice. It could increase serum insulin levels and decrease serum glucagons concentrations in STZ-DM rats. The results of immunohistochemical stain demonstrated that the number of islet beta cells was increased and that of islet a cells was decreased in STZ-DM rats. It could also decrease the serum glucose concentrations and increase liver glucogen contents in adrenaline-induced hyperglycemic mice.<br />Conclusion: DC has obvious anti-hyperglycemic effects in adrenaline-induced hyperglycemic mice and STZ-DM rats. Its mechanisms are stimulating the secretion of insulin from beta cells and inhibiting the secretion of glucagons from a cells, and it can probably decrease the decomposition of liver glucogen and increase the synthesis of liver glucogen.
- Subjects :
- Animals
Blood Glucose metabolism
Diabetes Mellitus, Experimental pathology
Drugs, Chinese Herbal isolation & purification
Epinephrine
Female
Glucagon blood
Glycogen metabolism
Hypoglycemia chemically induced
Hypoglycemia metabolism
Hypoglycemic Agents isolation & purification
Insulin blood
Liver metabolism
Male
Mice
Plants, Medicinal chemistry
Rats
Rats, Sprague-Dawley
Dendrobium chemistry
Diabetes Mellitus, Experimental blood
Drugs, Chinese Herbal pharmacology
Hypoglycemic Agents pharmacology
Islets of Langerhans drug effects
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1001-5302
- Volume :
- 29
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- Publication Type :
- Academic Journal
- Accession number :
- 15719686