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A functional glutathione S-transferase P1 gene polymorphism is associated with methamphetamine-induced psychosis in Japanese population.
- Source :
-
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics [Am J Med Genet B Neuropsychiatr Genet] 2005 May 05; Vol. 135B (1), pp. 5-9. - Publication Year :
- 2005
-
Abstract
- Several lines of evidence suggest that oxidative stress plays a role in the mechanisms of action of methamphetamine (MAP) in the human brain. Given the role of glutathione S-transferases (GSTs) in the protection against oxidative stress, genes encoding the GSTs have been considered as candidates for association studies of MAP abuse. This study was undertaken to investigate the role of the functional polymorphism of GSTP1 gene exon 5 (Ile105Val) in the pathogenesis of MAP abuse. Genotyping for GSTP1 gene polymorphism exon 5 (Ile105Val) in 189 MAP abusers and 199 normal controls was performed by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP). Association between GSTP1 gene polymorphism and clinical features (prognosis of psychosis (transient-type and prolonged-type), spontaneous relapse (positive and negative), and poly-substance abuse) of MAP abusers was evaluated. Significant differences in the frequency of both alleles (P = 0.026, odds ratio: 1.70, 95% confidence intervals (CI) 1.06-2.72) and genotypes (P = 0.029) between MAP abusers and controls were detected. In particular, a significant difference in both genotype frequency (P = 0.013) and allele frequency (P = 0.014, odds ratio: 1.84, 95% CI 1.13-2.97) between MAP abusers with psychosis (transient-type and prolonged-type) and controls was detected. Our findings suggest that the polymorphism (Ile105Val) on exon 5 of the GSTP1 gene may contribute to a vulnerability to psychosis associated with MAP abuse in Japanese population.<br /> (Copyright 2005 Wiley-Liss, Inc.)
- Subjects :
- Adolescent
Adult
Aged
Alleles
Female
Gene Frequency
Genotype
Glutathione S-Transferase pi
Glutathione Transferase metabolism
Humans
Isoenzymes metabolism
Japan
Male
Middle Aged
Psychoses, Substance-Induced etiology
Amphetamine-Related Disorders complications
Glutathione Transferase genetics
Isoenzymes genetics
Methamphetamine poisoning
Polymorphism, Genetic
Psychoses, Substance-Induced genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1552-4841
- Volume :
- 135B
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 15729709
- Full Text :
- https://doi.org/10.1002/ajmg.b.30164