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Dual CD117 expression in gastrointestinal stromal tumor (GIST) and paraganglioma of Carney triad: a case report.
- Source :
-
International journal of surgical pathology [Int J Surg Pathol] 2005 Jan; Vol. 13 (1), pp. 87-92. - Publication Year :
- 2005
-
Abstract
- Carney triad is a rare syndrome, with only 20 complete cases reported. We report a 36-year-old white woman with complete Carney triad, including metastatic gastric stromal tumor (GIST), pulmonary chondroma, and nonfunctioning extra-adrenal paraganglioma. Immunohistochemistry was positive for CD34 and CD117 (c-kit) in the GIST, and positive for chromogranin and CD117 in the paraganglioma. Ultrastructural studies demonstrated skeinoid fibers in the GIST. To our knowledge, this is the 21st complete Carney triad case reported and the first report of dual expression CD117 in both GIST and paraganglioma, a finding with intriguing pathogenetic implications related to the organization of the autonomic nervous system.
- Subjects :
- Adult
Antigens, CD34 analysis
Antineoplastic Agents therapeutic use
Biomarkers, Tumor analysis
Chondroma chemistry
Chondroma therapy
Chromogranins analysis
Drug Therapy
Female
Gastrointestinal Stromal Tumors chemistry
Gastrointestinal Stromal Tumors therapy
Humans
Leiomyosarcoma chemistry
Leiomyosarcoma therapy
Lung Neoplasms chemistry
Lung Neoplasms therapy
Palliative Care
Paraganglioma, Extra-Adrenal chemistry
Paraganglioma, Extra-Adrenal therapy
Syndrome
Chondroma pathology
Gastrointestinal Stromal Tumors pathology
Leiomyosarcoma secondary
Lung Neoplasms pathology
Paraganglioma, Extra-Adrenal pathology
Proto-Oncogene Proteins c-kit analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1066-8969
- Volume :
- 13
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International journal of surgical pathology
- Publication Type :
- Academic Journal
- Accession number :
- 15735861
- Full Text :
- https://doi.org/10.1177/106689690501300113