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The human leucocyte antigen-DRB1*1302-DQB1*0609-DPB1*0201 haplotype may be a strong genetic marker for aspirin-induced urticaria.
- Source :
-
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology [Clin Exp Allergy] 2005 Mar; Vol. 35 (3), pp. 339-44. - Publication Year :
- 2005
-
Abstract
- Background: Urticaria/angioedema is a common aspirin-induced allergy; however, its pathogenic mechanism is not understood.<br />Objective: In order to uncover the genetic mechanism, we studied the associations of the human leucocyte antigen (HLA) genotypes in patients with aspirin-induced urticaria compared with aspirin-intolerant asthma and normal control in a Korean population.<br />Methods: Ninety-four aspirin-induced urticaria patients presenting urticaria/angioedema-induced by both ASA and NSAID (50 had underlying chronic urticaria) and showing positive responses on oral aspirin challenge test, 76 aspirin-intolerant asthmatics with positive responses on lysine-aspirin bronchoprovocation test, and 185 normal healthy controls were enrolled. HLA-DRB1, DQB1, and DPB1 genotypings were performed by direct DNA sequencing analysis.<br />Results: The allele frequencies of HLA-DRB1(*)1302 (18.1%) and HLA-DQB1(*)0609 (10.1%) in aspirin-induced urticaria were significantly higher than in aspirin-intolerant asthma (5.3%, P=0.0004; 2.0%, P=0.0024) and in normal controls (8.1%, P=0.0005; 3.2%, P=0.0008), and they remained significant after correcting for multiple comparisons. The patients with these two HLA markers had a significantly younger age than patients without, while no associations were found in with respect to atopic status, a history of previous allergic diseases, total IgE level, or presence of underlying chronic urticaria (P>0.05, respectively). In haplotype analysis, the HLA-DRB1(*)1302-DQB1(*)0609-DPB1(*)0201 was significantly higher in the aspirin-induced urticaria (8.0%) than in the aspirin-intolerant asthma (0.7%, P=0.0014) and normal controls (2.0%, P=0.0006).<br />Conclusion: These findings suggest that the HLA-DRB1(*)1302-DQB1(*)0609-DPB1(*)0201 may be a strong genetic marker to determine the aspirin-induced urticaria phenotype.
- Subjects :
- Adult
Alleles
Case-Control Studies
Female
Genetic Markers
HLA-DP Antigens genetics
HLA-DP beta-Chains
HLA-DQ Antigens genetics
HLA-DQ beta-Chains
HLA-DRB1 Chains
Haplotypes
Humans
Korea
Male
Middle Aged
Anti-Inflammatory Agents, Non-Steroidal adverse effects
Aspirin adverse effects
HLA-DR Antigens genetics
Urticaria chemically induced
Urticaria genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0954-7894
- Volume :
- 35
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 15784113
- Full Text :
- https://doi.org/10.1111/j.1365-2222.2004.02197.x