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Therapeutic administration of Budesonide ameliorates allergen-induced airway remodelling.
- Source :
-
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology [Clin Exp Allergy] 2005 Mar; Vol. 35 (3), pp. 388-96. - Publication Year :
- 2005
-
Abstract
- Background: Airway inflammation and remodelling are important pathophysiologic features of chronic asthma. Although current steroid use demonstrates anti-inflammatory activity, there are limited effects on the structural changes in the lung tissue.<br />Objective: We have used a mouse model of prolonged allergen challenge that exhibits many of the salient features of airway remodelling in order to investigate the anti-remodelling effects of Budesonide.<br />Methods: Treatment was administered therapeutically, with dosing starting after the onset of established eosinophilic airway inflammation and hyper-reactivity.<br />Results: Budesonide administration reduced airway hyper-reactivity and leukocyte infiltration in association with a decrease in production of the Th2 mediators, IL-4, IL-13 and eotaxin-1. A reduction in peribronchiolar collagen deposition and mucus production was observed. Moreover, our data show for the first time that, Budesonide treatment regulated active transforming growth factor (TGF)-beta signalling with a reduction in the expression of pSmad 2 and the concomitant up-regulation of Smad 7 in lung tissue sections.<br />Conclusions: Therefore, we have determined that administration of Budesonide modulates the progression of airway remodelling following prolonged allergen challenge via regulation of inflammation and active TGF-beta signalling.
- Subjects :
- Animals
Asthma immunology
Asthma metabolism
Bronchi immunology
Bronchi metabolism
Bronchi pathology
Bronchial Hyperreactivity drug therapy
Bronchoalveolar Lavage Fluid immunology
Chemokine CCL11
Chemokines, CC immunology
Collagen metabolism
Extracellular Matrix metabolism
Extracellular Matrix pathology
Female
Image Processing, Computer-Assisted
Interleukin-13 immunology
Interleukin-4 immunology
Lymphocyte Activation drug effects
Mice
Mice, Inbred BALB C
Models, Animal
Mucus
Signal Transduction drug effects
Time Factors
Transforming Growth Factor beta metabolism
Allergens administration & dosage
Anti-Asthmatic Agents therapeutic use
Asthma drug therapy
Budesonide therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0954-7894
- Volume :
- 35
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 15784120
- Full Text :
- https://doi.org/10.1111/j.1365-2222.02193.x