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[DRESS syndrome to allopurinol: a case in Dakar].

Authors :
Dia D
Ba-Fall K
Bouldouyre M
Chevalier B
Debonne JM
Source :
Dakar medical [Dakar Med] 2004; Vol. 49 (2), pp. 114-5.
Publication Year :
2004

Abstract

We report a case of DRESS syndrome also called drug hypersensitivity reaction occurring a 47 years old Senegalese man who has been taking allopurinol for 3 months. That drug was prescribed for peripheric arthralgias associated to a hyperuricemia. He presented a generalised pruritus, cutaneous lesions, fever and facial oedema. On the biological examens, hyperleucocytosis with hypereosinophilia and hyperlymphocytosis associated to the presence of segmented basophiles. In addition, a hepatic cytolysis and cholestasis were documented. Liver ultrasound was normal. The hemocults were negative. These following serologies have been performed and were negative: hepatitis B and C, Epstein Barr-virus, cytomegalovirus, syphilis, toxoplasma and parvovirus B19. The anti-nuclear and anti-DNA antibodies were negative. A favourable clinical evolution was remarked after allopurinol treatment withdrawal. A desquamation occurred after 6 days and hemogram turned out to the normal as well as the hepatic tests after 2 weeks. The virologic examens performed 2 months later were unremarkable. This case point out the importance of the early diagnosis and quick withdrawal of the drug in order to prevent serious forms leading to the 10% of death.

Details

Language :
French
ISSN :
0049-1101
Volume :
49
Issue :
2
Database :
MEDLINE
Journal :
Dakar medical
Publication Type :
Academic Journal
Accession number :
15786619