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A prospective trial of steroid withdrawal after renal transplantation treated with cyclosporine and mizoribine in children: results obtained between 1990 and 2003.
- Source :
-
Pediatric transplantation [Pediatr Transplant] 2005 Apr; Vol. 9 (2), pp. 232-8. - Publication Year :
- 2005
-
Abstract
- A prospective trial of adrenocorticostertoid (steroid) withdrawal after pediatric renal transplantation was begun in 1990. Ninety-four pediatric renal transplant recipients were enrolled in our multicenter study. Immunosuppressive therapy with cyclosporine (CyA), methylprednisolone (MPL), and mizoribine (MZ) was started after transplantation. MPL was reduced to administration on alternate days in 69 patients (73.4%) and was withdrawn in 27 patients (28.7%). Rejection episodes occurred in nine patients (33.3%) after withdrawal of MPL. It occurred within 3 months after withdrawal of MPL in two patients and more than 6 months in the others. Among them, two patients lost the grafts. Thirteen-year patient survival rate and graft survival rate were 94.6 and 83.1%, respectively. Forty-four of the 94 patients reached their final height. Mean final height was 155.0 cm in males and 146.3 cm in females and their height standard deviation score was -2.6 s.d., the same as that at the time of transplantation. Management of growth retardation before transplantation and further reduction in the steroid dose after transplantation will increase the final height of children with chronic renal failure.
- Subjects :
- Adolescent
Body Height drug effects
Child
Child, Preschool
Drug Therapy, Combination
Female
Graft Rejection epidemiology
Graft Rejection prevention & control
Growth Disorders chemically induced
Humans
Male
Prognosis
Prospective Studies
Cyclosporine therapeutic use
Glucocorticoids administration & dosage
Immunosuppressive Agents therapeutic use
Kidney Transplantation adverse effects
Kidney Transplantation immunology
Methylprednisolone administration & dosage
Ribonucleosides therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1397-3142
- Volume :
- 9
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Pediatric transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 15787799
- Full Text :
- https://doi.org/10.1111/j.1399-3046.2005.00255.x