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Chronic tendon pathology: molecular basis and therapeutic implications.

Authors :
Riley G
Source :
Expert reviews in molecular medicine [Expert Rev Mol Med] 2005 Mar 24; Vol. 7 (5), pp. 1-25. Date of Electronic Publication: 2005 Mar 24.
Publication Year :
2005

Abstract

Tendons are frequently affected by chronic pain or rupture. Many causative factors have been implicated in the pathology, which until relatively recently was under-researched and poorly understood. There is now a greater knowledge of the molecular basis of tendon disease. Most tendon pathology (tendinopathy) is associated with degeneration, which is thought to be an active, cell-mediated process involving increased turnover and remodelling of the tendon extracellular matrix. Degradation of the tendon matrix is mediated by a variety of metalloproteinase enzymes, including matrix metalloproteinases and 'aggrecanases'. Neuropeptides and other factors released by stimulated cells or nerve endings in or around the tendon might influence matrix turnover, and could provide novel targets for therapeutic intervention.

Details

Language :
English
ISSN :
1462-3994
Volume :
7
Issue :
5
Database :
MEDLINE
Journal :
Expert reviews in molecular medicine
Publication Type :
Academic Journal
Accession number :
15796783
Full Text :
https://doi.org/10.1017/S1462399405008963