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A dissociation of encoding and retrieval processes in the human hippocampus.
- Source :
-
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2005 Mar 30; Vol. 25 (13), pp. 3280-6. - Publication Year :
- 2005
-
Abstract
- The hippocampal formation performs two related but distinct memory functions: encoding of novel information and retrieval of episodes. Little evidence, however, resolves how these two processes are implemented within the same anatomical structure. Here we use high-resolution functional magnetic resonance imaging to show that distinct subregions of the hippocampus are differentially involved in encoding and retrieval. We found that regions early in the hippocampal circuit (dentate gyrus and CA fields 2 and 3) were selectively active during episodic memory formation, whereas a region later in the circuit (the subiculum) was active during the recollection of the learning episode. Different components of the hippocampal circuit likely contribute to different degrees to the two basic memory functions.
- Subjects :
- Adult
Analysis of Variance
Evoked Potentials physiology
Functional Laterality physiology
Hippocampus blood supply
Humans
Image Processing, Computer-Assisted methods
Magnetic Resonance Imaging methods
Nerve Net blood supply
Neural Pathways blood supply
Time Factors
Brain Mapping
Hippocampus physiology
Mental Recall physiology
Nerve Net physiology
Neural Pathways physiology
Recognition, Psychology physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1529-2401
- Volume :
- 25
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 15800182
- Full Text :
- https://doi.org/10.1523/JNEUROSCI.3420-04.2005