Can application of serine protease inhibitors TPCK and TLCK provide evidence for possible involvement of serine protease Omi/HtrA2 in imatinib mesylate-induced cell death of BCR-ABL-positive human leukemia cells?

Subjects

Subjects :

Benzamides
High-Temperature Requirement A Serine Peptidase 2
Humans
Imatinib Mesylate
Leukemia metabolism
Mitochondrial Proteins
Tosyllysine Chloromethyl Ketone pharmacology
Tumor Cells, Cultured
Leukemia drug therapy
Piperazines pharmacology
Protein Kinase Inhibitors pharmacology
Pyrimidines pharmacology
Serine Endopeptidases metabolism
Serine Proteinase Inhibitors pharmacology
Tosylphenylalanyl Chloromethyl Ketone pharmacology

Details

Language :

English

ISSN :

0887-6924

Volume :

19

Issue :

6

Database :

MEDLINE

Journal :

Leukemia

Publication Type :

Report

Accession number :

15800674

Full Text :

https://doi.org/10.1038/sj.leu.2403701