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Therapeutic targets for prevention and regression of progressive fibrosing renal diseases.
- Source :
-
Current opinion in investigational drugs (London, England : 2000) [Curr Opin Investig Drugs] 2005 Mar; Vol. 6 (3), pp. 255-61. - Publication Year :
- 2005
-
Abstract
- Renal fibrosis complicates most chronic renal diseases, leading to a progressive loss of function and ultimately resulting in terminal renal failure. Molecular mechanisms underlying the development and progression of renal fibrosis have been increasingly identified, and much progress has been made towards a better understanding of the roles of different growth factors/cytokines and regulators of matrix turnover, as well as of the interactions between renal inflammation and fibrosis. This review focuses on recent advances in the identification of novel targets, as well as the development of new therapeutic tools for use in the treatment of progressive fibrosing renal diseases. Using our growing knowledge, treatment strategies need to be identified that prevent progression more effectively, as well as inducing regression of developed renal fibrosis. This is likely by combining compounds that interfere with a variety of targets simultaneously.
- Subjects :
- Angiotensin-Converting Enzyme Inhibitors therapeutic use
Animals
Bone Morphogenetic Protein 7
Bone Morphogenetic Proteins therapeutic use
Chemotaxis, Leukocyte
Fibrosis pathology
Glomerulosclerosis, Focal Segmental pathology
Glomerulosclerosis, Focal Segmental therapy
Humans
Kidney Diseases pathology
Kidney Tubules pathology
Lymphocyte Activation
Relaxin therapeutic use
Renin-Angiotensin System
Transforming Growth Factor beta therapeutic use
Hepatocyte Growth Factor therapeutic use
Kidney Diseases prevention & control
Kidney Diseases therapy
Platelet-Derived Growth Factor therapeutic use
Transforming Growth Factors therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1472-4472
- Volume :
- 6
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Current opinion in investigational drugs (London, England : 2000)
- Publication Type :
- Academic Journal
- Accession number :
- 15816501