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Synthesis of vaccinia virus polypeptides in the presence of hydroxyurea.

Synthesis of vaccinia virus polypeptides in the presence of hydroxyurea.

Authors :
Katz E
Margalith E
Winer B
Source :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 1974 Nov; Vol. 6 (5), pp. 647-50.
Publication Year :
1974

Abstract

Hydroxyurea (5 x 10(-3) M) inhibits the development of vaccinia virus in HeLa cells early after infection and prevents the synthesis of viral deoxyribonucleic acid. In the presence of hydroxyurea, late viral polypeptides are not formed, as observed by electrophoresis on polyacrylamide gels.

Details

Language :
English
ISSN :
0066-4804
Volume :
6
Issue :
5
Database :
MEDLINE
Journal :
Antimicrobial agents and chemotherapy
Publication Type :
Academic Journal
Accession number :
15825321
Full Text :
https://doi.org/10.1128/AAC.6.5.647