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Synthesis, assembly, and processing of the Env ERVWE1/syncytin human endogenous retroviral envelope.
- Source :
-
Journal of virology [J Virol] 2005 May; Vol. 79 (9), pp. 5585-93. - Publication Year :
- 2005
-
Abstract
- Syncytin is a fusogenic protein involved in the formation of the placental syncytiotrophoblast layer. This protein is encoded by the envelope gene of the ERVWE1 proviral locus belonging to the human endogenous retrovirus W (HERV-W) family. The HERV-W infectious ancestor entered the primate lineage 25 to 40 million years ago. Although the syncytin fusion property has been clearly demonstrated, little is known about this cellular protein maturation process with respect to classical infectious retrovirus envelope proteins. Here we show that the cellular syncytin protein is synthesized as a glycosylated gPr73 precursor cleaved into two mature proteins, a gp50 surface subunit (SU) and a gp24 transmembrane subunit (TM). These SU and TM subunits are found associated as homotrimers. The intracytoplasmic tail is critical to the fusogenic phenotype, although its cleavage requirements seem to have diverged from those of classical retroviral maturation.
- Subjects :
- Amino Acid Sequence
Cell Line
Glycosylation
Humans
Molecular Sequence Data
Protein Precursors metabolism
Protein Subunits genetics
Receptors, G-Protein-Coupled genetics
Sequence Alignment
Endogenous Retroviruses metabolism
Gene Products, env biosynthesis
Pregnancy Proteins biosynthesis
Receptors, G-Protein-Coupled metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0022-538X
- Volume :
- 79
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of virology
- Publication Type :
- Academic Journal
- Accession number :
- 15827173
- Full Text :
- https://doi.org/10.1128/JVI.79.9.5585-5593.2005