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M2/M4 muscarinic receptor binding in the anterior cingulate cortex in schizophrenia and mood disorders.
- Source :
-
Brain research bulletin [Brain Res Bull] 2005 May 15; Vol. 65 (5), pp. 397-403. - Publication Year :
- 2005
-
Abstract
- We have previously shown a decrease in [(3)H]pirenzepine binding to M1/M4 muscarinic receptors in the anterior cingulate cortex in schizophrenia but not in major depression or bipolar disorder. The present study aimed to extend these findings by examining the binding of [(3)H]AF-DX 384 to M2/M4 receptors in the same cohort of subjects. Using quantitative autoradiography we measured [(3)H]AF-DX 384 binding in the anterior cingulate cortex of 15 schizophrenia, 15 bipolar, 15 major depression and 15 control cases. Post-mortem tissue was obtained from the Stanley Foundation Brain Bank. [(3)H]AF-DX 384 binding had a homogenous distribution amongst the layers of the anterior cingulate cortex, was higher in males than in females and declined with prolonged storage of tissue. An inverse correlation between [(3)H]AF-DX384 binding and age of onset of the disease was observed in the schizophrenia group suggesting that the earlier the age at onset the higher the binding was. In the depression group, there was a significant effect of gender on [(3)H]AF-DX 384 binding with females having lower binding in comparison to males. In the bipolar group, there was a significant inverse correlation between antipsychotic medication and [(3)H]AF-DX 384 binding, suggesting that the higher the dose of medication the lower the binding was. No differences in [(3)H]AF-DX 384 binding were seen between the four groups. The present results provide no evidence of M2/M4 receptor alterations in the anterior cingulate cortex in schizophrenia and affective disorders and extend the body of evidence implicating cortical M1 but not M2 involvement in the pathology and pharmacotherapy of schizophrenia.
- Subjects :
- Adult
Age of Onset
Analysis of Variance
Autoradiography
Brain Mapping
Case-Control Studies
Dose-Response Relationship, Drug
Female
Gyrus Cinguli drug effects
Humans
Male
Middle Aged
Organ Size
Parasympatholytics pharmacology
Pirenzepine pharmacology
Postmortem Changes
Protein Binding drug effects
Regression Analysis
Sex Factors
Tritium pharmacology
Gyrus Cinguli metabolism
Mood Disorders metabolism
Pirenzepine analogs & derivatives
Receptor, Muscarinic M2 metabolism
Receptor, Muscarinic M4 metabolism
Schizophrenia metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0361-9230
- Volume :
- 65
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Brain research bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 15833594
- Full Text :
- https://doi.org/10.1016/j.brainresbull.2005.02.007