Back to Search Start Over

Different firing patterns induced by veratridine and aconitine in injured dorsal root ganglion neurons.

Different firing patterns induced by veratridine and aconitine in injured dorsal root ganglion neurons.

Authors :
Duan JH
Xing JL
Yang J
Hu SJ
Source :
Sheng li xue bao : [Acta physiologica Sinica] [Sheng Li Xue Bao] 2005 Apr 25; Vol. 57 (2), pp. 169-74.
Publication Year :
2005

Abstract

Ectopic spontaneous activity originated from the injured dorsal root ganglion (DRG) neurons in rats was recorded through single dorsal root fiber. The firing patterns induced by veratridine and aconitine, inhibitors of inactivation gate of sodium channel operating on different binding sites, were compared. In the same neuron, veratridine (1.5 approximately 5.0 micromol/L) caused slow wave oscillations of interspike intervals (ISIs), while aconitine (10 approximately 200 micromol/L) caused tonic firing. Moreover, even if the background firing patterns were various and the reagent concentrations used were different, veratridine and aconitine still induced slow wave oscillations and tonic firing patterns, respectively. The results suggest that veratridine and aconitine induce different firing patterns in injured DRG neurons, which may relate to their inhibitory effects on different binding sites of the sodium channel.

Details

Language :
English
ISSN :
0371-0874
Volume :
57
Issue :
2
Database :
MEDLINE
Journal :
Sheng li xue bao : [Acta physiologica Sinica]
Publication Type :
Academic Journal
Accession number :
15834502