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Nanoscale size effect of magnetic nanocrystals and their utilization for cancer diagnosis via magnetic resonance imaging.
- Source :
-
Journal of the American Chemical Society [J Am Chem Soc] 2005 Apr 27; Vol. 127 (16), pp. 5732-3. - Publication Year :
- 2005
-
Abstract
- Since the use of magnetic nanocrystals as probes for biomedical system is attractive, it is important to develop optimal synthetic protocols for high-quality magnetic nanocrystals and to have the systematic understanding of their nanoscale properties. Here we present the development of a synthetically controlled magnetic nanocrystal model system that correlates the nanoscale tunabilities in terms of size, magnetism, and induced nuclear spin relaxation processes. This system further led to the development of high-performance nanocrystal-antibody probe systems for the diagnosis of breast cancer cells via magnetic resonance imaging.
- Subjects :
- Animals
Antibodies, Monoclonal chemistry
Antibodies, Monoclonal, Humanized
Biocompatible Materials chemical synthesis
Biocompatible Materials chemistry
Cell Line, Tumor
Humans
Trastuzumab
Breast Neoplasms diagnosis
Iron chemistry
Magnetic Resonance Imaging methods
Magnetics
Nanostructures chemistry
Sulfides chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0002-7863
- Volume :
- 127
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 15839639
- Full Text :
- https://doi.org/10.1021/ja0422155