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Association of vitamin-D and calcitonin receptor gene polymorphism in paediatric nephrolithiasis.
- Source :
-
Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2005 Jun; Vol. 20 (6), pp. 773-6. Date of Electronic Publication: 2005 Apr 26. - Publication Year :
- 2005
-
Abstract
- We investigated the role of vitamin-D receptor gene (VDR) and calcitonin receptor (CTR) gene polymorphism in childhood nephrolithiasis in the north Indian population. A control group of 60 healthy paediatric individuals (age range 4-16 years) and 50 paediatric patients (age range 2-14 years) with kidney stones were examined. Polymorphism in both genes (VDR and CTR) was detected by using PCR-based restriction analysis. There was a statistically significant difference between the two groups for the genotypes of the VDR gene Fok-I polymorphism (P =0.007) and the CTR gene (P =0.048) polymorphism. The odds ratio (95% Confidence Interval) for the C allele in those at risk of stone disease was 1.83 (0.82-4.09) in VDR gene polymorphism and 1.99 (0.90-4.39) in the case of CTR gene polymorphism. Our results suggest that the effects of VDR (Fok-I) and CTR gene polymorphism contribute to the understanding of the pathogenesis of urinary calculi. It is also suggestive of a potential candidate gene in the search for genetic causes of paediatric calcium oxalate nephrolithiasis.
- Subjects :
- Adolescent
Case-Control Studies
Child
Child, Preschool
Confidence Intervals
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Odds Ratio
Polymerase Chain Reaction
Prospective Studies
Kidney Calculi genetics
Polymorphism, Genetic
Receptors, Calcitonin genetics
Receptors, Calcitriol genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0931-041X
- Volume :
- 20
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Pediatric nephrology (Berlin, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 15856322
- Full Text :
- https://doi.org/10.1007/s00467-005-1846-4