Back to Search
Start Over
Xanthones from the roots of Polygala caudata and their antioxidation and vasodilatation activities in vitro.
- Source :
-
Planta medica [Planta Med] 2005 Apr; Vol. 71 (4), pp. 372-5. - Publication Year :
- 2005
-
Abstract
- Three new xanthones, 2-hydroxy-1,6,7-trimethoxyxanthone (1), 1,4-dimethoxy-2,3-methylenedioxyxanthone (2), and 7-hydroxy-1,2-dimethoxyxanthone (3), together with five known compounds, 2,7-dihydroxy-1-methoxyxanthone (4), 1-methoxy-2,3-methylenedioxyxanthone (5), 7-hydroxy-1-methoxyxanthone (6), euxanthone (1,7-dihydroxyxanthone) (7), and gentitein (1,3,7-trihydroxyxanthone) (8), were isolated from the roots of Polygala caudata. Their structures were established on the basis of spectral evidence. In the antioxidation activity screening in vitro with luminol chemiluminescence methods, compounds 1 - 5 and 7 and 8 showed H2O2 scavenger activity, with a scavenging effect of 58.4 - 94.5% at 10 microg/mL, and 26.0 - 84.7% at 2 microg/mL. Compounds 4 and 8 also exhibited scavenging effects on the reactive oxygen free radicals produced by macrophage respiratory bursts, with a scavenging effect of 71.7% and 63.4% at 10 microg/mL, 41.2% and 47.8% at 2 microg/mL, respectively. In the vasodilatation assay, compounds 4 - 7 exhibited relaxing activity on the contractions evoked by KCl in Wistar rat thoracic aorta rings in a dose-dependent manner.
- Subjects :
- Animals
Antioxidants administration & dosage
Antioxidants therapeutic use
Aorta drug effects
Dose-Response Relationship, Drug
Muscle, Smooth, Vascular drug effects
Plant Extracts administration & dosage
Plant Extracts therapeutic use
Plant Roots
Rats
Rats, Wistar
Respiratory Burst drug effects
Vasodilation drug effects
Vasodilator Agents administration & dosage
Vasodilator Agents therapeutic use
Xanthones administration & dosage
Xanthones pharmacology
Xanthones therapeutic use
Antioxidants pharmacology
Phytotherapy
Plant Extracts pharmacology
Polygala
Vasodilator Agents pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0032-0943
- Volume :
- 71
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Planta medica
- Publication Type :
- Academic Journal
- Accession number :
- 15856419
- Full Text :
- https://doi.org/10.1055/s-2005-864108