Back to Search
Start Over
[Effect of xiaokeling concentration fluid on mRNA expression of insulin-like growth factor-1 in sciatic nerve of Streptozotocin-induced diabetic rats].
- Source :
-
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences [Zhong Nan Da Xue Xue Bao Yi Xue Ban] 2005 Feb; Vol. 30 (1), pp. 49-52. - Publication Year :
- 2005
-
Abstract
- Objective: To investigate the effect of xiaokeling concentration fluid on insulin-like growth factor-1 (IGF-1) mRNA expression in sciatic nerve of Streptozotocin-induced diabetic rats.<br />Methods: Thirty diabetic rats were randomly divided into model group, mecobalamin tablets group, and xiaokeling concentration fluid group. The IGF-1 mRNA level in sciatic nerve of each group was determined after 8 weeks by relative quantity RT-PCR.<br />Results: The IGF-1 mRNA level in sciatic nerve of diabetic rats between xiaokeling concentration fluid group, mecobalamin tablets group and normal group showed no significant difference ( P = 0.213, P = 0.822, P = 0.304 ), while was significantly higher than that of the model group ( P < 0.05 ). IGF-1 mRNA level was negatively correlated with the level of blood sugar (P < 0.05).<br />Conclusion: IGF-1 mRNA level decreased in sciatic nerve of diabetic rats. Xiaokeling concentration fluid can increase the IGF-1 mRNA level in sciatic nerve of diabetic rats. Xiaokeling concentration fluid is involved in the regulation of IGF-1 expression, and probably prevents diabetic peripheral neuropathy from deteriorating.
- Subjects :
- Animals
Diabetes Mellitus, Experimental drug therapy
Diabetic Neuropathies prevention & control
Drugs, Chinese Herbal therapeutic use
Hypoglycemic Agents pharmacology
Hypoglycemic Agents therapeutic use
Insulin-Like Growth Factor I genetics
Male
RNA, Messenger biosynthesis
RNA, Messenger genetics
Random Allocation
Rats
Receptor, IGF Type 1
Reverse Transcriptase Polymerase Chain Reaction
Diabetes Mellitus, Experimental metabolism
Drugs, Chinese Herbal pharmacology
Insulin-Like Growth Factor I biosynthesis
Sciatic Nerve metabolism
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1672-7347
- Volume :
- 30
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 15871187