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In situ formation of blends by photopolymerization of poly(ethylene glycol) dimethacrylate and polylactide.
- Source :
-
Biomacromolecules [Biomacromolecules] 2005 May-Jun; Vol. 6 (3), pp. 1615-22. - Publication Year :
- 2005
-
Abstract
- Blends of cross-linked poly(ethylene glycol) dimethacrylate (PEGDMA) and poly(d,l-lactide) (PLA) were prepared by mixing photoactive PEGDMA (molecular mass: 875 g/mol) and PLA, and subsequently photopolymerizing the mixture with visible light. The effects of PLA molecular mass and mass fraction on the rheological properties of the PEGDMA/PLA mixtures, and on the degree of methacrylate vinyl conversion (DC), as well as blend miscibility, microstructure, mechanical properties, in vitro swelling behavior, and cell responses were studied. PLA-2K (molecular mass: 2096 g/mol) and PLA-63K (molecular mass: 63 000 g/mol) formed miscible and partially miscible blends with cross-linked PEGDMA, respectively. The addition of the PLA-2K did not affect the immediate or post-cure (>24 h) DC of the PEGDMA upon photopolymerization. However, the addition of PLA-63K decreased the immediate DC of the PEGDMA, which can be increased through extending the curing time or post-curing period. Compared to the cross-linked neat PEGDMA and PLA-2K/PEGDMA blends, PLA-63K/PEGDMA blends were significantly stronger, stiffer, and tougher. Both types of blends and the cross-linked PEGDMA swelled when soaked in a phosphate buffered saline (PBS) solution. The attachment and spreading of MCT3-E1 cells increased with increasing PLA-63K content in the blends. The facile and rapid formation of PEGDMA/PLA blends by photopolymerization represents a simple and efficient approach to a class of biomaterials with a broad spectrum of properties.
- Subjects :
- Acrylates pharmacology
Animals
Cells, Cultured
Mice
Polyesters pharmacology
Polyethylene Glycols pharmacology
Polyethylene Glycols radiation effects
Polymers pharmacology
Polymers radiation effects
Tensile Strength drug effects
Tensile Strength radiation effects
Acrylates chemical synthesis
Photic Stimulation methods
Polyesters chemical synthesis
Polyethylene Glycols chemical synthesis
Polymers chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1525-7797
- Volume :
- 6
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Biomacromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 15877385
- Full Text :
- https://doi.org/10.1021/bm0500648